Loading Jobs...

Despite promising results in an earlier trial, people taking the experimental drug intepirdine in the Phase III MINDSET trial did not see any substantial benefits in memory and thinking compared to those who took a placebo. These disappointing results feel like yet another setback, but Dr Clare Walton our Research Communications Manager explains why we should still be optimistic.

A drug to manage the symptoms of dementia

Intepirdine was being tested as an add-on to existing Alzheimer’s medications. It wasn’t expected to slow down the brain damage caused by Alzheimer’s, but based on earlier studies, researchers were hopeful that it would go further than the existing drugs to help people cope with the symptoms of dementia.

Given that we haven’t seen a drug approved for any form of dementia since 2002, new approaches to treat the symptoms and to slow the disease are both urgently needed.

Over 1000 people with mild to moderate Alzheimer’s disease took part in the trial. They took either the experimental drug or a placebo every day for 6 months, on top of a stable daily dose of donepezil, the most common treatment for Alzheimer’s.

At the end of the study, there were no significant differences in memory and thinking abilities between those who took the drug and those who took the placebo. There were also no improvements in how well people were able to complete their daily activities such as dressing, cooking and using public transport.

The conclusion – that intepirdine does not work as a new drug for people with Alzheimer’s.

Broadening the focus of drug discovery

It’s true that drug discovery for Alzheimer’s disease has been riddled with negative results, but this latest failure isn’t a reason to lose hope. Up until now, most Alzheimer’s drug research has focused on a very narrow range of targets. Drugs in development have either focused on the build-up of amyloid plaques, or have tried to change the imbalance of chemicals called neurotransmitters in the brain. This is what intepirdine does.

Although we know both of these mechanisms are important in Alzheimer’s, we also know of several other pathways that go wrong and contribute to disease progression. Alzheimer’s Society has recently committed £50m as a founding funder of the UK Dementia Research Institute, which will fund over 400 scientists to investigate the underlying causes of all forms of dementia. By exploring a much wider range of disease mechanisms, their research aims to unlock the doors to many alternative treatment approaches.

Dementia Research Institute graphic
Plans for the UK Dementia Research Institute

 

Researchers within the UK Dementia Research Institute, and indeed across our £30m research portfolio, are looking into a number of exciting leads. These include: the critical role that cells and chemicals of the immune system play in dementia; the way in which connections between brain cells are disrupted early in the disease; what changes in the complex relationship between blood vessels and brain cells as dementia takes hold; and more exploratory work such as the role of sleep and gut bacteria in predisposing people to dementia.

Working across these diverse research areas and casting our net more widely should dramatically increase our chances of finding new drugs that really work.

Dr Doug Brown, our Director of Research and Development, said: ‘The UK Dementia Research Institute is a ground-breaking initiative that could not have arrived at a better time. As the number of people living with dementia in the UK is set to reach 1 million by 2021, the stakes are too high to fail.’

Time is of the essence

Of course for people living with dementia now, time is still the most important issue. With another drug failure comes the disappointment that it will be a few years before we see the next promising drug trial deliver its results. While we wait, we need to look at ways to shortcut the drug development process – which is the focus of our Drug Discovery programme. It tests whether drugs already in use for other health conditions such as diabetes, rheumatoid arthritis or high blood pressure, can work for people with dementia too, potentially reducing development time in half.

We’re also investing heavily into care research that looks at non-pharmacological ways to help people with dementia manage their symptoms and to be supported to live in their communities as well as possible for as long as possible.

 

Secure Healthcare Solutions is looking for nurses in Birmingham, Walsall, Telford, Shrewsbury, Dudley and Stoke in NHS and also well known Private Hospitals.

We are offering flexible pay rates/benefits;
· £20 – £37 per hour.
· £100 on completion of 100 hours payable on 200 hours
· FREE mandatory training
· FREE immunisations
· Dedicated consultant available 24/7
· Excellent referral fees – OPTION 1 – £500 on completion of 400 hours OPTION 2 – 0.40p for each nursing hour worked
· Help and support with revalidation
· On site financial advice for tax planning

There has never been a better time to join Secure Healthcare Solutions

in a full or part time nursing job.

Secure Healthcare Solutions is looking for nurses in Birmingham, Walsall, Telford, Shrewsbury, Dudley and Stoke in NHS and also well known Private Hospitals.

We are offering flexible pay rates/benefits;
· £20 – £37 per hour.
· £100 on completion of 100 hours payable on 200 hours
· FREE mandatory training
· FREE immunisations
· Dedicated consultant available 24/7
· Excellent referral fees – OPTION 1 – £500 on completion of 400 hours OPTION 2 – 0.40p for each nursing hour worked
· Help and support with revalidation
· On site financial advice for tax planning

There has never been a better time to join Secure Healthcare Solutions

in a full or part time nursing job.

When faced with illness or immobility, it can be a struggle to carry out everyday activities that you may have once performed with ease. Our discreet personal care service is designed to support you with your day-to-day living, as well as providing you with the encouragement and emotional support that you may need to remain living independently. Our personal care service can assist you with personal hygiene needs ( washing, dressing, continence care) administering medication, at a time to suit your convenience. Maintaining your dignity is of paramount importance to us, which is why our Carers will ensure you feel comfortable at all times.

The best person to know what support you need to remain as independent as possible in your own home is you. That is why everything we do is designed around your needs and goals. These can be relatively simple like help with shopping through to high dependency 24 hour care.

  • Housekeeping
  • Personal care
  • Companionship
  • Support with information and advice
  • Housing support
  • High dependency care
  • Live-in care
  • Respite care
  • Medication management
  • Hospital to Home service
  • Complex and specialist care

Home care  can be arranged on an hourly, daily, weekly basis or a much longer plan to suit your needs. We  provides in-home care and support services to people so they can live as independently as possible in their own homes and communities. We support people to live life the way they choose.

Our trained caring friendly staff have your Dignity and respect at the forefront of delivering personalised care in the comfort of your own home. When providing home care for yourself or a family member or friend, we take the time to get to know you and make sure you are continually happy with the care you received and the staff that support you.

With Secure Healthcare as your home care service provider, you will enjoy personalised service built around your needs. Secure Healthcare pride ourselves on treating people with the same care, kindness and dignity that we would expect our loved ones to be treated.

We pride ourselves on ensuring  persons needing support are Safe, our care treatment and support helps you to maintain quality of life based on best available evidence, our staff involve and treat you with compassion, kindness, dignity and respect. We ensure our services are responsive to your needs and our management ensure high quality care is provided based on an individuals needs.

Living independently at home is something most of us would like to do for as long as possible. When that time comes to make the decision to ask for extra support to continue to live independently as much as possible, our home care services are tailored for exactly that. If you wish to learn more about how we can support you, please contact us and let one of our advisers come to see you and your family for a more detailed plan on how we can support you.

Secure Healthcare Solutions Newport provides bespoke and high quality care at home and support so you can enjoy a personalised home care service built around your needs.

Living independently at home is something most of us would like to do for as long as possible. When that time comes to make the decision to ask for extra support to continue to live independently as much as possible, our home care services are tailored for exactly that.

Our trained caring friendly staff have your Dignity and respect at the forefront of delivering personalised care in the comfort of your own home. When providing home care for yourself or a family member or friend, we take the time to get to know you and make sure you are continually happy with the care you received and the staff that support you.

Home care can be arranged on an hourly, daily, weekly basis or a much longer plan to suit your needs. We  provides in-home care and support services to people so they can live as independently as possible in their own homes and communities. We support people to live life the way they choose.

The best person to know what support you need to remain as independent as possible in your own home is you. That is why everything we do is designed around your needs and goals. These can be relatively simple like help with shopping through to high dependency 24 hour care.

  • Housekeeping
  • Personal care
  • Domiciliary care
  • Companionship
  • Support with information and advice
  • Housing support
  • High dependency care
  • Live-in care
  • Respite care
  • Medication management
  • Hospital to Home service
  • Complex and specialist care

Let us help you get the care you need for the life you want.

If you wish to learn more about how we can support you, please contact us and let one of our advisers come to see you and your family for a more detailed plan on how we can support you.

Secure Healthcare Solutions and Wolves Community Trust, the registered charity of Wolverhampton Wanderers FC, have officially launched the partnership to bring walking football to the city during the 2017/18 season.
 
Walking football is a growing national phenomenon aimed at helping the over 40s and those with limited mobility to remain fit and active, while still pursuing their love for football in a fun and sociable environment.
 
The basic premise behind the 6-a-side sport, which can be played either indoors or outdoors, is that running is not allowed. Additionally, there’s low impact tackling and the ball must remain below head height.
 
The partnership between WCT and Secure Healthcare Solutions was officially launched at Wolves’ training ground and attended by first team players, Roderick Miranda, Ruben VinagreLeo Bonatini and Ivan Cavaleiro, who all participated in a demonstration match.
 
Roderick Miranda said “I have no doubt that these walking football sessions will become very popular. It’s a fun activity and it lets older people continue playing the sport they love.”
 
Robbie Steeles, managing director of Secure Healthcare Solutions, said: “We know first-hand how crucial it is for people’s health and wellbeing that they try to be as active and sociable as possible. Walking football is a great way to achieve both these and it is something that can be done by almost everyone. There are also many people in the city who live very isolated lives due to their limited mobility, so I’d definitely encourage them to get involved with walking football.”
 
Will Clowes, Wolves Community Trust general manager, said: “The trust supports the local community through delivering projects relevant to sport, health, education, inclusion and community donations. Each year, the projects delivered by WCT reach around 25,000 local residents of all ages, genders, socio-economic and ethnic demographics.
 
“Over 4,000 participants are engaged in sports programmes alone, with over 85 weekly sessions being delivered to the communities. Football is played by people of all ages and abilities, but as people get older they naturally become less mobile and that’s what’s so great about walking football. It’s the ideal activity for those who want to continue playing, being active and enjoying the beautiful game, but without the intensity and physical demands.”
 
The walking football sessions take place at Bert Williams Leisure Centre, The Dormston Centre and Wolverhampton College (Wellington Road Campus). For further information on days and times pleasecontact Rachel Smith on rachelsmith@wolves.co.uk or 01902 687038/ 07532 411 166.

Susie Henley leads the free online course “The Many Faces of Dementia”, run by University College London (UCL). Here she explains the course and how you can sign up to learn more about rarer forms of dementia.

Susie Henley

Did you know that some forms of dementia can affect how people see the world around them? Or that they can cause problems with language and communication rather than just memory?

UCL’s popular, free online course, “The Many Faces of Dementia,” can teach you more about the lesser-known aspects of dementia.

The course uses videos from people with dementia, as well as discussions and articles from leading clinicians and researchers in the dementia field, to shed light on aspects of dementia that may come as a surprise.

It’s accessible, with jargon-free information; the online platform FutureLearn also means that you can dip in and out when you have time. You can complete the whole course by spending about two hours a week on it over the four-week run.

It’s a very sociable forum, with many learners commenting on the various steps and supporting each other as they learn about each other’s stories and reasons for being there.

Different aspects of dementia

Each week tackles a different aspect of dementia.

In week one, the course looks at Familial Alzheimer’s disease (FAD), rare forms of Alzheimer’s disease that are inherited, and how this affects the whole family. It also explores how research with members of these families has been enormously helpful in understanding the more common, non-inherited forms of Alzheimer’s disease.

Week two covers frontotemporal dementia (FTD), an umbrella term for a lesser-known cluster of young-onset dementias that can affect social skills and behaviour or language. In these forms of dementia, memory is relatively preserved in the early stages, so it’s very different to what most people think of as ‘dementia’. Often people with these forms of dementia have struggled to get a diagnosis and to understand what’s going on.

In the third week, we look at dementia with Lewy bodies (DLB), and typical features of this. This includes seeing things that aren’t there (hallucinations) or believing things that aren’t true (delusions). These symptoms can occur in other types of dementia, but tend to be a defining feature in dementia with Lewy bodies. We hear from families living with this dementia, and the professionals who try to help manage and minimise the impact of hallucinations.

Finally, week four talks about Posterior Cortical Atrophy (PCA), the rare variant of Alzheimer’s disease that author Terry Pratchett had. The course uses videos and pictures to show what life is like for someone with Posterior Cortical Atrophy, whose brain can no longer process visual and spatial information correctly.

 

Useful information for everyone

Whilst the course focuses on rarer dementia types, it’s also relevant to anyone working or living with people with all types of dementia. People with the more common forms of Alzheimer’s disease and vascular dementia can also experience these sorts of symptoms at some point.

Learners to date have been a mixture of professionals, family members, students and people with dementia. We’ve had lots of very positive feedback about how useful the new information they’ve gleaned from the course is, and how they’ve learned from each other too.

Expert staff from UCL also pop in to answer questions and comments during the week; there is a special ‘Q&A’ feature at the end of each week, where the most popular learner questions are answered online every Sunday night.

So if you are interested in exploring a bit more about these sides of dementia, or you know someone who is, encourage them to sign up and have a look.

Looking for a career with legs? Here’s why healthcare is a great choice.  If you’re passionate about helping people, finding a job in the healthcare industry can be one of the most rewarding career choices there is.  Don’t believe us? Here are ten reasons that prove healthcare could be a step in the right direction for your career:

You’ll be in demand!

Healthcare is the fastest growing job sector in the workforce. With potentially fewer candidates from the EU and more existing staff retiring, it will be crucial for the NHS and social care sectors to attract more younger people.

  • The Royal College of Nursing says England is currently short of at least 20,000 nursing staff.
  • The Royal College of Midwives says the country needs 3,500 more midwives.

 

Healthcare pays

To attract the best candidates and professionals, healthcare providers and some care agencies offer high pay packages to recruit and retain the best care staff.

Choices, choices, choices

There are lots of different opportunities in healthcare – something for everyone. You can work in med tech, labs, or directly with patients in hospitals,care homes, clinics, nursing homes or private care agencies.

Get a free education

You can get free training or even all your education paid for. Due to the staffing shortages in the industry, you can find employers and government scholarships to cover your educational costs.

You’ll feel needed

Working in healthcare make a difference in people’s lives. Caring for people and helping others lead healthy lives is satisfying and important.

Meet different people

Healthcare workers interact with different people everyday, including patients, doctors, medical staff. In some fields, you’ll interact with researchers, technology experts, or scientists.

Health care is exciting

You never know what’s going to happen, and have to stay one your toes, solve problems and make good decisions. Every day is different.

You can move up

There are lots of opportunities for advancement in healthcare. You can get promoted or move up to related healthcare fields that pay more.  A Band 9 Nurse pay package can easily reach the :  £78,629 – £99,437 mark.

Variety

You can change specialities. If you’re interested in paediatrics, complex care , mental health , dementia, you can move into those areas when the opportunities arise.

It’s a fast-paced environment

Filled with challenges, and offering the chance to work with people from all walks of life, there’ll never be a dull day in this industry.

By solving each individual problem in whatever way your job allows, you’ll experience a sense of variety and know that you’re working towards a good cause. Teamwork is a big part of the job too, and you’ll get great job satisfaction knowing you’re working towards a meaningful joint goal with your colleagues. If you’re sick of being bored at work or feeling like your job has no real purpose, finding your perfect position in the healthcare industry could be the perfect antidote.

You have many options for a career in healthcare, the fastest growing field today. Get free information from great schools today!

View all available healthcare jobs now.

Secure Healthcare Solutions is proud to support Wolves Community Trust during the 2017/18 season.
 
Wolves Community Trust, the registered charity of Wolverhampton Wanderers FC, supports the local community through delivering projects relevant to sport, health, education, inclusion and community donations.
 
We have teamed up with the trust to bring the fantastic sport of walking football to people in and around Wolverhampton. The aim of walking football is to help older people, or those with limited mobility, remain active and fit, while still pursuing their love for the beautiful game in a fun and sociable environment.
 
Each year, the projects delivered by Wolves Community trust reach around 25,000 local residents of all ages, genders, socio-economic and ethnic demographics. Over 4,000 participants are engaged in sports programmes alone, with over 85 weekly sessions being delivered to the communities.
 
For further information about the great work Wolves Community Trust does, and to find out more about walking football sessions, visit www.wolvescommunitytrust.org.uk/.

Secure Healthcare Solutions Albrighton provides bespoke and high quality care at home and support so you can enjoy a personalised home care service built around your needs.

Living independently at home is something most of us would like to do for as long as possible. When that time comes to make the decision to ask for extra support to continue to live independently as much as possible, our home care services are tailored for exactly that.

Our trained caring friendly staff have your Dignity and respect at the forefront of delivering personalised care in the comfort of your own home. When providing home care for yourself or a family member or friend, we take the time to get to know you and make sure you are continually happy with the care you received and the staff that support you.

Home care can be arranged on an hourly, daily, weekly basis or a much longer plan to suit your needs. We provide in-home care and support services to people so they can live as independently as possible in their own homes and communities. We support people to live life the way they choose.

The best person to know what support you need to remain as independent as possible in your own home is you. That is why everything we do is designed around your needs and goals. These can be relatively simple like help with shopping through to high dependency 24 hour care.

  • Housekeeping
  • Personal care
  • Domiciliary care
  • Companionship
  • Support with information and advice
  • Housing support
  • High dependency care
  • Live-in care
  • Respite care
  • Medication management
  • Hospital to Home service
  • Complex and specialist care

Let us help you get the care you need for the life you want.

If you are from Albrighton and wish to learn more about how we can support you, please contact us and let one of our advisers come to see you and your family for a more detailed plan on how we can support you.